Abstract |
This study aims to investigate the effect of zearalenone supplementation on rat metabolism. Rats received biweekly intragastric administration of zearalenone mycotoxin (3 mg/kg body weight) for 2 weeks. Urine and plasma samples after zearalenone administration were analyzed by NMR-based metabolomics. Zearalenone exposure significantly elevated the plasma levels of glucose, lactate, N-acetyl glycoprotein, O-acetyl glycoprotein, and propionate but reduced the plasma levels of tyrosine, branched-chain amino acids, and choline metabolites. Zearalenone supplementation decreased the urine levels of butyrate, lactate, and nicotinate. However, it increased the urine levels of allantoin, choline, and N-methylnicotinamide at 0-8 h after the last zearalenone administration and those of 1-methylhistidine, acetoacetate, acetone, and indoxyl sulfate at 8-24 h after the last zearalenone administration. These results suggest that zearalenone exposure can cause oxidative stress and change common systemic metabolic processes, including cell membrane metabolism, protein biosynthesis, glycolysis, and gut microbiota metabolism.
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Authors | Guangmang Liu, Tao Yan, Jing Wang, Zhiqing Huang, Xiaoling Chen, Gang Jia, Caimei Wu, Hua Zhao, Bai Xue, Liang Xiao, Jiayong Tang |
Journal | Journal of agricultural and food chemistry
(J Agric Food Chem)
Vol. 61
Issue 46
Pg. 11212-21
(Nov 20 2013)
ISSN: 1520-5118 [Electronic] United States |
PMID | 24164354
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Female
- Magnetic Resonance Spectroscopy
- Metabolomics
- Plasma
(chemistry)
- Rats
(genetics, metabolism)
- Rats, Sprague-Dawley
- Urine
(chemistry)
- Zearalenone
(metabolism, toxicity)
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