Abstract |
Despite the chemotherapy is successful in inducing remission of hematologic malignancy, this disease also has a high probability of relapse; besides, the toxicity of chemotherapy for these patients can not be avoided. Researchers have been attempting to eliminate tumor cells by immunotherapy. Recently, various leukemia-associated antigens (LAA) that are recognized by cytotoxic T cell (CTL) in the context of HLA class I molecules have been identified. These LAA include WT1, PR-3, RHAMM, BCR-ABL and Aur-A. On the basis of these findings, various clinical trials of immunotherapy for hematologic malignancy including tumor peptide vaccination, adoptive T cell therapy, NK cell therapy and dendritic cells- cytokine induced killer (DC-CIK) cell therapy are on going. In this review, the current status and future feasibility of cellular immunotherapy for leukemia are discussed.
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Authors | Hong Tian, Guang-Hua Chen, Yang Xu, Man Qiao, Hui-Wen Liu, De-Pei Wu |
Journal | Zhongguo shi yan xue ye xue za zhi
(Zhongguo Shi Yan Xue Ye Xue Za Zhi)
Vol. 21
Issue 5
Pg. 1326-30
(Oct 2013)
ISSN: 1009-2137 [Print] China |
PMID | 24156459
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Humans
- Immunotherapy, Adoptive
- Leukemia
(therapy)
- T-Lymphocytes, Cytotoxic
(immunology)
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