Abstract | OBJECTIVE: METHODS: Three test groups used dentifrices which contained either: 1) 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate in a calcium base (experimental); 2) 1450 ppm fluoride as sodium fluoride in a silica base (positive control); or 3) no fluoride in a calcium base (negative control). The study participants were residents of the city of Chengdu, Sichuan Province, China. In order to take part, subjects had to have at least one non-cavitated primary root caries lesion. A total of 412 subjects completed the study. They were aged from 50 to 70 years (mean age 64 +/- 4.1 years) and 53.6% were female. Efficacy for arresting and reversal of primary root caries was assessed by clinical hardness measures and through the use of the Electrical Caries Monitor. RESULTS: After three months of product use, clinical hardness measures showed that 27.7%, 24.6%, and 13.1% of lesions had improved in the experimental, positive, and negative control groups, respectively, and 0.7%, 4.5%, and 16.8% had become worse, respectively. The differences in the distribution of lesion change between the negative control group and both the experimental (p < 0.001) and positive control (p = 0.001) were statistically significant. The Electrical Caries Monitor was also used as an objective measure of lesion severity. The end values increased from baseline to the three-month examinations, but none of the differences between the groups attained statistical significance. After six months, clinical hardness measures showed that only one lesion (0.7%) was worse than at the baseline examination-in the experimental group compared to 9.0% and 18.2% in the positive and negative control groups, respectively. In addition, 61.7%, 56.0%, and 27.0%, respectively, showed improvement for the three groups. The differences in the distribution of lesion change scores between the negative control group and both the experimental (p < 0.001) and positive control (p < 0.001) were statistically significant, as was the difference between the experimental group and the positive control (p = 0.006). The Electrical Caries Monitor end values for the experimental, positive, and negative control groups at the six-month examination were 7.9, 1.9 mega omega(s), and 387 kilo omegas(s), respectively. The differences between the negative control group and both the experimental (p < 0.001) and positive control (p < 0.001) were statistically significant. The difference between the experimental and positive control groups was also statistically significant (p = 0.03). CONCLUSION:
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Authors | D Y Hu, W Yin, X Li, Y Feng, Y P Zhang, D Cummins, L R Mateo, R P Ellwood |
Journal | The Journal of clinical dentistry
(J Clin Dent)
Vol. 24 Spec no A
Pg. A23-31
( 2013)
ISSN: 0895-8831 [Print] United States |
PMID | 24156137
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cariostatic Agents
- Dentifrices
- Phosphates
- fluorophosphate
- Silicon Dioxide
- Arginine
- Fluorides
- Calcium
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Topics |
- Aged
- Arginine
(therapeutic use)
- Calcium
(therapeutic use)
- Cariostatic Agents
(therapeutic use)
- Dental Caries Activity Tests
(instrumentation)
- Dental Plaque Index
- Dentifrices
(therapeutic use)
- Double-Blind Method
- Electric Impedance
- Female
- Fluorides
(therapeutic use)
- Follow-Up Studies
- Gingiva
(pathology)
- Hardness
- Humans
- Male
- Middle Aged
- Phosphates
(therapeutic use)
- Root Caries
(classification, prevention & control)
- Silicon Dioxide
(therapeutic use)
- Tooth Remineralization
(methods)
- Toothbrushing
- Treatment Outcome
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