Abstract | BACKGROUND: METHODS: In this randomized, double-blinded, placebo-controlled study, 204 healthy inpatients who were undergoing elective surgery with general anaesthesia were enrolled. Patients were divided into two groups: the palonosetron group ( palonosetron 0.075 mg i.v.; n=102) and the placebo group ( normal saline i.v.; n=102). The treatments were given after the induction of anaesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 72 h after surgery were evaluated. RESULTS: The incidence of PONV was lower in the palonosetron group compared with the placebo group during the 0-24 h (33% vs 47%) and 0-72 h period (33% vs 52%) (P<0.05), but not during the 24-72 h postoperative period (6% vs 11%). The incidence of nausea was also significantly lower in the palonosetron group than in the placebo group during the 0-24 and 0-72 h period (P<0.05), but not during the 24-72 h postoperative period. However, there were no significant differences in the incidence of vomiting, and the use of rescue anti-emetics between the groups. CONCLUSIONS:
Palonosetron 0.075 mg i.v. effectively reduced the incidence of PONV during the first 72 h after operation, with most of the reduction occurring in the first 24 h.
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Authors | H R Chun, I S Jeon, S Y Park, S J Lee, S H Kang, S I Kim |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 112
Issue 3
Pg. 485-90
(Mar 2014)
ISSN: 1471-6771 [Electronic] England |
PMID | 24154700
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiemetics
- Isoquinolines
- Quinuclidines
- Palonosetron
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Topics |
- Adult
- Aged
- Antiemetics
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Isoquinolines
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Palonosetron
- Postoperative Nausea and Vomiting
(diagnosis, epidemiology, prevention & control)
- Quinuclidines
(adverse effects, therapeutic use)
- Risk Assessment
- Sample Size
- Surgical Procedures, Operative
- Treatment Outcome
- Young Adult
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