Abstract | BACKGROUND AND AIM OF THE STUDY: METHODS: Twelve patients with CaHD, 18 with CS and 10 'normal' subjects were recruited. Patients with CaHD underwent cardiac catheterization and echocardiography. 5-HTplt and 5-HTpls was sampled in blood from the femoral vein, right and left ventricle, and left antecubital fossa vein. RESULTS: Levels of 5-HTpls and 5-HTplt were significantly higher in patients with CaHD (median 5-HTpls 325 nmol/l and 5-HTplt 18.9 nmol/10(9) platelets) and CS (median 5-HTpls 155 nmol/l and 5-HTplt 16.4 nmol/10(9) platelets) when compared to healthy controls (median 5-HTpls 9 nmol/l and 5-HTplt 3.7 nmol/10(9) platelets; p < 0.0001 and p = 0.003, respectively). There was a significant increase in 5-HTplt and 5-HTpls between the femoral vein and right heart (p = 0.007 and p = 0.0002, respectively). There was no significant difference in 5-HTplt or 5-HTpls between the right and left side of the heart, irrespective of the presence of a patent foramen ovale or of left-sided CaHD. CONCLUSION: Plasma and platelet 5-HT levels are elevated in patients with CaHD. Despite exposure to similar levels of intracardiac plasma and platelet 5-HT, the development of valve dysfunction is heterogeneous. This suggests that individual heart valves have a susceptibility to the development of valvular dysfunction which is not related solely to plasma or platelet 5-HT levels.
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Authors | Sanjeev Bhattacharyya, Anita Jagroop, Dorothy M Gujral, Carl Hayward, Christos Toumpanakis, Martyn Caplin, Dimitri P Mikhailidis, Joseph Davar |
Journal | The Journal of heart valve disease
(J Heart Valve Dis)
Vol. 22
Issue 3
Pg. 400-7
(May 2013)
ISSN: 0966-8519 [Print] England |
PMID | 24151767
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Blood Platelets
(metabolism)
- Blood Specimen Collection
(methods)
- Carcinoid Heart Disease
(blood, diagnosis, physiopathology)
- Cardiac Catheterization
(methods)
- Echocardiography
(methods)
- Female
- Heart Valve Diseases
(blood, diagnosis, physiopathology)
- Heart Valves
(diagnostic imaging, physiopathology)
- Humans
- Male
- Middle Aged
- Pilot Projects
- Serotonin
(blood, metabolism)
- Statistics as Topic
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