Study on anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice.

Abstract

The objective of the paper was to study the anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice, and to preliminarily explore its mechanism of action. Mice were made into S180 solid tumor model, grouped and administered with the extracts; tumor inhibition rate was measured by harvesting the tumors, and serum IL-2 and IL-4 levels were measured by taking blood samples. Total glycosides of Radix paeoniae rubra significantly inhibited the growth of tumor cells in tumor-bearing organisms, enhanced the cytotoxic activity of NK cells, and increased the serum IL-2 and IL-4 levels. Total glycosides of Radix paeoniae rubra have some anti-tumor effect in vivo, which might have been accomplished through the regulation of the immune system.

• Authors: Wanpeng Xu, Wei Zhong, Jinlan Liu, Hong Liu, Bing Zhu
• Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM (Afr J Tradit Complement Altern Med) Vol. 10 Issue 3 Pg. 580-5 ( 2013) ISSN: 2505-0044 [Electronic] Nigeria
• PMID: 24146492 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Glycosides
• Interleukin-2
• Plant Extracts
• Interleukin-4

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Glycosides (pharmacology, therapeutic use)
• Interleukin-2 (blood)
• Interleukin-4 (blood)
• Killer Cells, Natural (metabolism)
• Male
• Mice
• Mice, Inbred Strains
• Neoplasms (blood, drug therapy, immunology)
• Paeonia (chemistry)
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Plant Roots