Abstract |
The chemical investigation of soft coral Sinularia kavarattiensis is described. It yielded furano- sesquiterpene carboxylic acids 1 and 2 and their methyl esters 3 and 4. Semi-synthesis of furano- sesquiterpene carboxylic acid 1 gave amide derivatives 5-12. Structures of all the compounds were established by IR, NMR and mass spectral analysis. Interestingly all compounds are selectively potent on leukemia cell line. All these compounds were screened for cytotoxic activity against five human cancer cell lines ( leukemia, prostate, lung, breast and cervix). Among these compounds 9 and 10 showed promising activity against leukemia and prostate cancer cell lines.
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Authors | Singanaboina Rajaram, Udugu Ramulu, Dasari Ramesh, Dudem Srikanth, Papri Bhattacharya, Peddikotla Prabhakar, Shasi V Kalivendi, Katragadda Suresh Babu, Yenamandra Venkateswarlu, Suryakiran Navath |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 23
Issue 23
Pg. 6234-8
(Dec 01 2013)
ISSN: 1464-3405 [Electronic] England |
PMID | 24144848
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Amides
- Furans
- Sesquiterpenes
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Topics |
- Amides
(chemistry, pharmacology)
- Animals
- Anthozoa
(chemistry)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Furans
(chemistry, pharmacology)
- HeLa Cells
- Humans
- MCF-7 Cells
- Molecular Structure
- Neoplasms
(chemistry, drug therapy)
- Sesquiterpenes
(chemistry, pharmacology)
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