[Moebius syndrome. Clinical case report].

Abstract

BACKGROUND:

Moebius syndrome (MBS) is an infrequent disease, having an incidence of 1 in 10,000 births, mainly characterized by a congenital bilateral facial paralysis due to an agenesia of the sixth and seventh cranial nerves. In addition, orofacial and limb anomalies are frequently found in these patients. The diagnosis is fundamentally based on different clinical manifestations of the disorder.

CLINICAL CASE:

a female newborn with the clinical picture of Moebius syndrome is presented, and genetic or environmental aspects are discussed. Since the use of misoprostol for abortion and inducing uterine activity in combination with NSAIDs, the number of newborns with MBS associated with this drug has increased. Nowadays, either genetic or environmental factors are associated with MBS.

CONCLUSIONS:

it is necessary that the general and medical community be aware of the risk of teratogenic effects of misoprostol, and the usefulness of genetic counseling whenever there is a newborn with Moebius syndrome.

• Authors: Yusvisaret Palmer-Morales, Rosario Elena Zárate-Márquez, Roberto Prince-Vélez, Roberto González-Méndez, Thania Ayerim Zamarripa-Sandoval, Nahim Verdugo-Salazar, Victor Gabriel Torres-Félix, Remigio Salcido-Daniel, Pedro Valdez-Hernández, Andrés Morfín-Vela
• Journal: Revista medica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc) 2013 Sep-Oct Vol. 51 Issue 5 Pg. 584-6 ISSN: 2448-5667 [Electronic] Mexico
• Vernacular Title: Síndrome de Moebius. Informe de un caso clínico.
• PMID: 24144154 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Female
• Humans
• Infant, Newborn
• Mobius Syndrome (diagnosis)