Mechanism of suppression of phagocytic and metabolic activity of neutrophils and production of proinflammatory cytokines during chronic poisoning with organophosphorus compounds.

Experiments on albino outbred rats showed that chronic poisoning with organophosphorus compounds (Russian VX, and sarin) for 30 days in a total dose of 0.3 DL50 (0.01 DL50 daily) is followed by a decrease in phagocytic and metabolic activity of neutrophils. The reduction of functional activity of monocyte phagocytic system was stipulated by the stimulation of N-cholinergic receptors of these cells. These changes were accompanied by a decrease in blood concentration of proinflammatory cytokines (TNF-α, IL-1β, and IL-6).
AuthorsP F Zabrodskii, V A Grishin, V K Borodavko
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 155 Issue 4 Pg. 464-6 (Aug 2013) ISSN: 1573-8221 [Electronic] United States
PMID24143369 (Publication Type: Journal Article)
Chemical References
  • Cholinesterase Inhibitors
  • Cytokines
  • Inflammation Mediators
  • Nicotinic Agonists
  • Organothiophosphorus Compounds
  • S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate
  • Nicotine
  • Sarin
  • Animals
  • Animals, Outbred Strains
  • Cholinesterase Inhibitors (toxicity)
  • Cytokines (metabolism)
  • Female
  • Inflammation Mediators
  • Lethal Dose 50
  • Male
  • Neutrophils (drug effects, physiology)
  • Nicotine (toxicity)
  • Nicotinic Agonists (toxicity)
  • Organothiophosphorus Compounds (toxicity)
  • Phagocytosis (drug effects)
  • Rats
  • Sarin (toxicity)

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