Abstract | PURPOSE: MATERIALS AND METHODS: From December 2005 to March 2008, 18 KS patients with a 47, XXY karyotype were treated with initial intramuscular injections of long-acting testosterone undecanoate (Nebido®, 1000 mg/4 mL) at baseline and second injections after six weeks. An additional four injections were administered at intervals of 12 weeks after the second injection. BMD was measured at the lumbar spine (L2-4), the left femoral neck and Ward's triangle, using dual energy X-ray absorptiometry. Medical histories, physical examinations and prostate specific antigen, hematology and serum chemistry were conducted for each patient. In addition, total testosterone and sex hormone-binding globulin levels were measured. RESULTS: Following testosterone replacement, mean serum total testosterone increased significantly from baseline (0.90 vs. 4.51 ng/mL, p<0.001), and total testosterone rose to normal levels after replacement in all patients. The mean BMD of the lumbar spine increased significantly (0.91 vs. 0.97 g/cm², p<0.001). Similar increases of BMD were also observed at the femoral neck, but this increase was not significant. CONCLUSION:
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Authors | Dae Gi Jo, Hyo Serk Lee, Young Min Joo, Ju Tae Seo |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 54
Issue 6
Pg. 1331-5
(Nov 2013)
ISSN: 1976-2437 [Electronic] Korea (South) |
PMID | 24142635
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Bone Density
(drug effects)
- Female
- Hormone Replacement Therapy
(methods)
- Humans
- Klinefelter Syndrome
(drug therapy)
- Male
- Testosterone
(therapeutic use)
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