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Anti-tau antibodies: hitting the target.

Abstract
Immunotherapies targeting tau in mouse models of human tauopathies could have disease-modifying effects. In this issue of Neuron, Yanamandra et al. (2013) use tau antibodies, which effectively block tau seeding in culture, to attenuate tauopathy and improve cognition in mutant tau mouse models.
AuthorsTodd E Golde, Jada Lewis, Nikolaus R McFarland
JournalNeuron (Neuron) Vol. 80 Issue 2 Pg. 254-6 (Oct 16 2013) ISSN: 1097-4199 [Electronic] United States
PMID24139027 (Publication Type: Introductory Journal Article, Comment)
CopyrightCopyright © 2013 Elsevier Inc. All rights reserved.
Chemical References
  • Antibodies, Monoclonal
  • tau Proteins
Topics
  • Animals
  • Antibodies, Monoclonal (therapeutic use)
  • Brain (metabolism)
  • Cognition Disorders (drug therapy)
  • Humans
  • Tauopathies (drug therapy)
  • tau Proteins (antagonists & inhibitors, immunology)

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