Abstract | BACKGROUND: METHODS: The treated group was administered prednisolone (0.75 mg/kg) orally on alternate days and the compared with the untreated control group. Gene mutations were investigated. The patients were examined for intelligence quotient adequate for age, brain natriuretic peptide, creatine kinase, and manual muscle testing before treatment and after the period 6 months to 2 years. RESULTS: Intelligence quotient scores of the treated increased to 6.5 ± 11.9 (mean ± standard deviation) were compared with the controls 2.1 ± 4.9 (P = 0.009). Intelligence quotient scores of the patients with nonsense point mutations improved significantly (21.0 ± 7.9) more than those with deletion or duplication (1.9 ± 9.0; P = 0.015). Motor function, such as time to stand up, of those treated improved significantly and brain natriuretic peptide level was reduced to a normal level after treatment in 15 patients (73%). CONCLUSIONS:
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Authors | Yuko Sato, Akemi Yamauchi, Mari Urano, Eri Kondo, Kayoko Saito |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 50
Issue 1
Pg. 31-7
(Jan 2014)
ISSN: 1873-5150 [Electronic] United States |
PMID | 24138948
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Adrenal Cortex Hormones
- Natriuretic Peptide, Brain
- Prednisolone
- Creatine Kinase
- prednylidene
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Child
- Child, Preschool
- Creatine Kinase
(blood)
- Female
- Humans
- Intelligence Tests
- Male
- Muscle Strength
(drug effects)
- Muscular Dystrophy, Duchenne
(complications, diagnosis, genetics)
- Natriuretic Peptide, Brain
(blood)
- Prednisolone
(analogs & derivatives, therapeutic use)
- Psychomotor Agitation
(drug therapy)
- Psychomotor Disorders
(drug therapy, etiology)
- Retrospective Studies
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