Transcortin and alpha 2u-globulin messenger RNA activities during turpentine-induced inflammation in the rat.

Abstract

Previously we have shown that the serum concentration of transcortin and alpha 2u-globulin markedly decreases during turpentine-induced inflammation. In the present study transcortin and alpha 2u-globulin mRNA from healthy rats and from animals with inflammation was translated in a rabbit reticulocyte lysate system. Female rats had higher levels of translatable transcortin mRNA than male animals and the level of mRNA for transcortin and alpha 2u-globulin decreased rapidly during inflammation. These results indicate that the sex difference in the serum level of transcortin and the changes in serum transcortin and alpha 2u-globulin during inflammation are mainly determined by differences in the mRNAs in the liver.

• Authors: D Faict, G Verhoeven, B Mertens, P De Moor
• Journal: Journal of steroid biochemistry (J Steroid Biochem) Vol. 23 Issue 3 Pg. 243-6 (Sep 1985) ISSN: 0022-4731 [Print] England
• PMID: 2413280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alpha-Globulins
• RNA, Messenger
• alpha 2u globulin
• Transcortin
• Turpentine

Topics

• Alpha-Globulins (genetics)
• Animals
• Chemical Precipitation
• Female
• Inflammation (blood, chemically induced, metabolism)
• Liver (metabolism)
• Male
• Nucleic Acid Hybridization
• Protein Biosynthesis (drug effects)
• RNA, Messenger (metabolism)
• Rats
• Rats, Inbred Strains
• Sex Factors
• Transcortin (genetics)
• Turpentine (pharmacology)