HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Ganglioside GM1 reduces white matter damage in neonatal rats.

Abstract
This study investigated the neuronal protective effect of monosialotetrahexosylganglioside (GM1) on the hypoxia-ischemia white matter damage (WMD) in neonatal rats. Brain hypoxia-ischemia was induced by bilateral carotid artery occlusion in 4-day-old neonatal rats. Bilateral carotid artery occlusion (BCAO) was performed in rats in WMD and GM1 groups, while in sham group; the rat bilateral carotid arteries were merely exposed without occlusion. Immunohistochemical staining was used to determine the expression of myelin basic protein (MBP), glial fibrillary acidic protein (GFAP), and beta-amyloid precursor protein (beta-APP). In addition, suspension test, slope test, and open-field test were carried out on day 26 after BCAO to determine the neurobehavioral function. The percentage of MBP-positive cells was decreased while beta-APP-and GFAPpositive cells were increased in WMD group. After treated with GM1, the percentage of MBP-positive cells increased significantly than WMD rats at post-operation 72 h and day 7. GFAP-positive cells and beta-APP-positive cells decreased significantly in WMD group at post-operation 72 h, day 7 and 26. The suspension test, slope test, and open-field test showed that neurobehavioral function was improved in ganglioside GM1 group compared with WMD group. Taken together, our findings suggested that ganglioside GM1 treatment reduces hypoxia-ischemia induced impairment of the neurobehavioral function in WMD in neonatal rats.
AuthorsXiao Rong, Wei Zhou, Chen Xiao-Wen, Li Tao, Juan Tang
JournalActa neurobiologiae experimentalis (Acta Neurobiol Exp (Wars)) Vol. 73 Issue 3 Pg. 379-86 ( 2013) ISSN: 1689-0035 [Electronic] Poland
PMID24129486 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid beta-Protein Precursor
  • Glial Fibrillary Acidic Protein
  • Myelin Basic Protein
  • G(M1) Ganglioside
Topics
  • Amyloid beta-Protein Precursor (metabolism)
  • Animals
  • Animals, Newborn
  • Carotid Artery Diseases (complications)
  • Disease Models, Animal
  • Female
  • G(M1) Ganglioside (therapeutic use)
  • Gene Expression Regulation (drug effects)
  • Glial Fibrillary Acidic Protein (metabolism)
  • Leukoencephalopathies (drug therapy, etiology)
  • Male
  • Myelin Basic Protein (metabolism)
  • Neurons (drug effects, metabolism, pathology)
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: