[Effects of metabolic syndrome on multi-vessel lesions of symptomatic intracranial atherosclerosis].

Abstract

OBJECTIVE:

To explore the effects of metabolic syndrome (MS) on multi-vessel lesions of symptomatic intracranial atherosclerosis.

METHODS:

During April 2009 and October 2010, a total of 139 consecutive hospitalized patients with symptomatic intracranial atherosclerosis were recruited to undergo magnetic resonance angiography (MRA) or/and CT angiography (CTA) or/and digital subtraction angiography (DSA) to measure the stenotic degree and numbers of intracranial atherosclerosis. They were divided into 2 groups according to lesion numbers: single and multi-vessel lesions. MS was defined by the criteria of the Adult Treatment Panel III to examine the incidences of MS. The risk factors were analyzed for multi-vessel lesions of symptomatic intracranial atherosclerosis to explore the relationship between MS and multi-vessel lesions.

RESULTS:

Among them, 210 intracranial atherosclerotic lesions were documented. Fifty-nine (42.4%) patients had two or more lesions (group with multi-vessel lesions). The incidence of MS was 70.5%. The rates of MS in groups of single and multi-vessel lesions were 56.3% and 89.8% respectively. And statistical significance existed between two groups (P < 0.001). Moreover, the number of MS components increased gradually with the number of lesions (P < 0.001). For the analysis of individual criteria for MS, only abnormal glycemia was found to be associated with multi-vessel lesions (P = 0.002). And multiple Logistic regression analysis showed that MS was associated with multi-vessel lesions of intracranial atherosclerosis (P = 0.001).

CONCLUSIONS:

MS is an independent predictor for multi-vessel lesions of intracranial atherosclerosis. And its intervention may be an important preventive strategy for intracranial multi-vessel atherosclerosis.

• Authors: Shuang-gen Zhu, You-ling Zhu, Zhi-fei Huang, Deng-yue Zhai, Ting-ting Zhang, Qun Zhou, Yan-fang Mu, De-zhi Liu, Wen-hua Liu, Ge-Lin Xu, Xin-feng Liu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 93 Issue 21 Pg. 1622-5 (Jun 04 2013) ISSN: 0376-2491 [Print] China
• PMID: 24125668 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• Intracranial Arteriosclerosis (complications, metabolism, pathology)
• Magnetic Resonance Angiography
• Male
• Metabolic Syndrome (epidemiology)
• Middle Aged
• Retrospective Studies
• Risk Factors
• Tomography, X-Ray Computed
• Young Adult