Abstract | BACKGROUND: METHODS: We enrolled 92 patients, including 34 with tuberculous pleurisy ( TBP), 36 with malignant pleuritis and 15 with parapneumonic effusions. IDO activity was evaluated using liquid chromatography/electrospray ionisation tandem mass spectrometry, and was estimated by calculating kynurenine-to- tryptophan ratio. RESULTS: Pleural fluid from patients with TBP had significantly higher kynurenine concentrations and significantly lower tryptophan concentrations, resulting in significantly higher IDO activity compared with pleural effusion or serum from non-tuberculous pleuritis (all P < 0.001). Pleural tissue from TBP showed enhanced IDO expression in epithelioid granuloma regions by immunohistochemistry. CONCLUSIONS: These results suggest that IDO is strongly involved in the pathogenesis of TBP.
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Authors | Y Suzuki, S Miwa, T Akamatsu, M Suzuki, M Fujie, Y Nakamura, N Inui, H Hayakawa, K Chida, T Suda |
Journal | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
(Int J Tuberc Lung Dis)
Vol. 17
Issue 11
Pg. 1501-6
(Nov 2013)
ISSN: 1815-7920 [Electronic] France |
PMID | 24125458
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Kynurenine
- Tryptophan
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(analysis)
- Chromatography, Liquid
- Female
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase
(analysis)
- Kynurenine
(analysis)
- Male
- Middle Aged
- Pleural Effusion
(enzymology)
- Prospective Studies
- Spectrometry, Mass, Electrospray Ionization
- Tandem Mass Spectrometry
- Tryptophan
(analysis)
- Tuberculosis, Pleural
(enzymology)
- Up-Regulation
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