Abstract |
In continuation with our studies concerning the synthesis, characterization and biological evaluation of nucleolipidic Ru(III) complexes, a novel design for this family of potential anticancer agents is presented here. As a model compound, a new uridine-based nucleolipid has been prepared, named HoUrRu, following a simple and versatile synthetic procedure, and converted into a Ru(III) salt. Stable formulations of this highly functionalized Ru(III) complex have been obtained by co-aggregation with either the zwitterionic lipid POPC or the cationic DOTAP, which have been subjected to an in-depth microstructural characterization, including DLS, SANS and EPR measurements. The in vitro bioactivity profile of HoUrRu, as a pure compound or in formulation with POPC or DOTAP, reveals high antiproliferative activity against MCF-7 and WiDr human cancer cell lines.
|
Authors | Daniela Montesarchio, Gaetano Mangiapia, Giuseppe Vitiello, Domenica Musumeci, Carlo Irace, Rita Santamaria, Gerardino D'Errico, Luigi Paduano |
Journal | Dalton transactions (Cambridge, England : 2003)
(Dalton Trans)
Vol. 42
Issue 48
Pg. 16697-708
(Dec 28 2013)
ISSN: 1477-9234 [Electronic] England |
PMID | 24121739
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Coordination Complexes
- Fatty Acids, Monounsaturated
- Phosphatidylcholines
- Quaternary Ammonium Compounds
- Ruthenium
- 1,2-dioleoyloxy-3-(trimethylammonium)propane
- 1-palmitoyl-2-oleoylphosphatidylcholine
- Uridine
|
Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Coordination Complexes
(chemistry, pharmacology)
- Drug Design
- Fatty Acids, Monounsaturated
(chemistry, pharmacology)
- Humans
- Neoplasms
(drug therapy)
- Phosphatidylcholines
(chemistry, pharmacology)
- Quaternary Ammonium Compounds
(chemistry, pharmacology)
- Ruthenium
(chemistry, pharmacology)
- Uridine
(analogs & derivatives, pharmacology)
|