Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: a randomized, controlled trial.

Abstract

OBJECTIVE:

This study aimed to determine the efficacy and safety of intralesional betamethasone in erosive oral lichen planus and to evaluate relapse of erosion.

STUDY DESIGN:

Patients were randomly assigned to the experimental group (1.4 mg intralesional betamethasone) or to the control group (8 mg intralesional triamcinolone acetonide), and they received injections once a week for 2 weeks. Erosive area and pain level were assessed on days 1, 7 ± 2, and 14 ± 2. If the lesion disappeared, any recurrence within the following 3 months was recorded.

RESULTS:

Twenty-nine participants in the experimental group and 30 in the control group completed the protocol. Healed percentage was higher with betamethasone (93.1%) than with triamcinolone (66.7%; P = .02), and final reduction in erosion area was greater in the experimental group (21.276 ± 21.064 mm(2)) than in the control group (11.5 ± 12.95 mm(2); P = .02). Reduction in pain level did not differ between groups. The proportion of participants with recurrent erosions was significantly lower in the experimental group (14.8%) than in the control group (45%; P = .04).

CONCLUSIONS:

Intralesional betamethasone may be used in the topical treatment of erosive oral lichen planus.

• Authors: Chuanxia Liu, Bing Xie, Yi Yang, Duanxian Lin, Caixia Wang, Mei Lin, Lin Ge, Hongmei Zhou
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 116 Issue 5 Pg. 584-90 (Nov 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 24119523 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Glucocorticoids
• Betamethasone
• Triamcinolone Acetonide

Topics

• Adolescent
• Adult
• Betamethasone (administration & dosage, therapeutic use)
• Female
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Injections, Intralesional
• Lichen Planus, Oral (drug therapy)
• Male
• Middle Aged
• Pain Measurement
• Recurrence
• Treatment Outcome
• Triamcinolone Acetonide (administration & dosage, therapeutic use)