Protein disulfide isomerase in thrombosis and vascular inflammation.

Abstract

Protein disulfide isomerase (PDI) catalyzes disulfide bond oxidation, reduction and isomerization during protein synthesis in the endoplasmic reticulum (ER). In addition to its critical role in the ER, in vitro and in vivo studies with blocking antibodies and conditional knockout mice have demonstrated that cell surface PDI is required for thrombosis, hemostasis and vascular inflammation in a manner dependent on its isomerase activity. This review will focus on our current understanding of the pathophysiologic role of PDI in regulating integrin-mediated platelet and neutrophil functions during vascular disease.

• Authors: J Cho
• Journal: Journal of thrombosis and haemostasis : JTH (J Thromb Haemost) Vol. 11 Issue 12 Pg. 2084-91 (Dec 2013) ISSN: 1538-7836 [Electronic] England
• PMID: 24118938 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2013 International Society on Thrombosis and Haemostasis.

Chemical References

• Protein Disulfide-Isomerases

Topics

• Endoplasmic Reticulum (enzymology)
• Humans
• Protein Disulfide-Isomerases (metabolism)
• Thrombosis (enzymology)
• Vasculitis (enzymology)