Egg-white-specific IgA and IgA2 antibodies in egg-allergic children: is there a role in tolerance induction?

Decreased serum food-specific IgA antibodies have been associated with allergic disease in cross-sectional, case-control studies. The purpose of this study was to prospectively compare egg-white-(EW)-specific IgA and IgA2 levels between egg-allergic children and children tolerating egg.
Seventeen egg-allergic children were followed prospectively. Total IgA, EW-specific IgA, and EW-specific IgA2 levels were measured in their sera with a sensitive ELISA. As negative controls were used children with no previous history of egg allergy. Egg-allergic children with or without concomitant milk allergy were evaluated as additional controls with measurement of casein-specific IgA.
After 2.5 ± 0.9 yrs, nine out of the 17 allergic children became tolerant and eight remained allergic to baked egg. Baseline EW-specific IgA2 levels were significantly lower in the egg-allergic subjects (median 23.9 ng/ml) compared with the negative control subjects (99.4 ng/ml) and increased significantly by 28% over the study time period in eight out of the nine allergic children that became tolerant to baked egg. There was no significant change over time in EW-specific IgA in any of the study groups. Non-milk-allergic subjects with concomitant egg allergy had almost threefold higher casein-specific IgA levels than the milk- and egg-allergic subjects (p = 0.025).
These results suggest a potential role for allergen-specific IgA2 antibodies in the induction of food tolerance. Furthermore, they support the hypothesis that immature or impaired production of allergen-specific IgA2 may be associated with the pathophysiology of food allergy, a defect that seems to be selective for the culprit allergen.
AuthorsGeorge N Konstantinou, Anna Nowak-Węgrzyn, Ramon Bencharitiwong, Luda Bardina, Scott H Sicherer, Hugh A Sampson
JournalPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (Pediatr Allergy Immunol) Vol. 25 Issue 1 Pg. 64-70 (Feb 2014) ISSN: 1399-3038 [Electronic] England
PMID24118158 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Copyright© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Chemical References
  • Allergens
  • Caseins
  • Egg Proteins, Dietary
  • Immunoglobulin A
  • Allergens (immunology)
  • Animals
  • Caseins (immunology)
  • Cattle
  • Child, Preschool
  • Egg Hypersensitivity (complications, immunology)
  • Egg Proteins, Dietary (immunology)
  • Female
  • Follow-Up Studies
  • Humans
  • Immune Tolerance
  • Immunity, Humoral
  • Immunoglobulin A (blood, immunology)
  • Infant
  • Male
  • Milk Hypersensitivity (complications, immunology)
  • Prospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: