There are many
cyclic peptides with diverse
biological activities, such as antibacterial activity, immunosuppressive activity, and anti-
tumor activity, and so on. Encouraged by natural
cyclic peptides with
biological activity, efforts have been made to develop
cyclic peptides with both genetic and synthetic methods. The genetic methods include phage display, intein-based
cyclic peptides, and
mRNA display. The synthetic methods involve individual synthesis, parallel synthesis, as well as split-and-pool synthesis. Recent development of
cyclic peptide library based on split-and-pool synthesis allows on-bead screening, in-
solution screening, and microarray screening of
cyclic peptides for
biological activity.
Cyclic peptides will be useful as receptor agonist/antagonist,
RNA binding molecule,
enzyme inhibitor and so on, and more
cyclic peptides will emerge as therapeutic agents and biochemical tools.