Objective. Anticyclic citrullinated
peptide antibodies (anti-CCP) testing is useful in the diagnosis of
rheumatoid arthritis (RA) with high specificity.
Arthritis is a very common clinical manifestation in children with
familial Mediterranean fever (FMF). The aim of the study was to show the presence of
anti-CCP antibodies in child individuals diagnosed with FMF. Material and Methods. The study groups comprised one hundred and twenty-six patients (126) diagnosed with FMF (female/male (n): 66/60) and 50 healthy controls (female/male (n): 25/25). Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum
C-reactive protein (CRP),
fibrinogen, and
anti-CCP antibody levels were measured. Results.
Anti-CCP was negative in healthy controls and also in all FMF patients. There was not a significant difference in
anti-CCP between the patient and the control groups. Our study has shown that
anti-CCP was correlated moderately with age (rs = 0.271; P = 0.0020), duration of illness (rs = 0.331; P < 0.0001), and
colchicine therapy (rs = 0.259; P = 0.004). Conclusion. Our data show that
anti-CCP antibodies are not associated with FMF.
Anti-CCP does not have a priority for identifying FMF
arthritis from the other inflammatory
arthritis.