Abstract | OBJECTIVE: METHODS: A total of 116 pediatric SLE cases from 1997 to 2011 were reviewed and patients with hypogammaglobulinemia (IgG < 500 mg/dl) were identified. The two cohorts were evaluated for association with age, sex, presence of lupus nephritis at SLE diagnosis, disease activity at diagnosis, initial IgG level, and drug treatment. RESULTS: CONCLUSION: Measurement of immunoglobulin levels during treatment in SLE could help identify patients with hypogammaglobulinemia who might require more aggressive follow-up to monitor for increased risk of infection and need for IVIG treatment. A prospective study is needed to validate associated risk factors identified in this study.
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Authors | E Lim, Y Tao, A J White, A R French, M A Cooper |
Journal | Lupus
(Lupus)
Vol. 22
Issue 13
Pg. 1382-7
(Nov 2013)
ISSN: 1477-0962 [Electronic] England |
PMID | 24106215
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Immunoglobulin G
- Immunoglobulins, Intravenous
- Immunosuppressive Agents
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Topics |
- Adolescent
- Agammaglobulinemia
(blood, diagnosis, drug therapy, ethnology, immunology)
- Age Factors
- Autoimmunity
- Biomarkers
(blood)
- Child
- Disease Progression
- Female
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulins, Intravenous
(therapeutic use)
- Immunosuppressive Agents
(therapeutic use)
- Lupus Erythematosus, Systemic
(blood, diagnosis, drug therapy, ethnology, immunology)
- Lupus Nephritis
(blood, immunology)
- Male
- Prognosis
- Retrospective Studies
- Risk Factors
- Sex Factors
- Time Factors
- White People
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