Abstract | PURPOSE: METHODS: Macrophages were differentiated from THP-1 cells after treatment with phorbol ester and used as the model of inflammatory cells, which were treated by specimens from glass-ionomer cements(GC), composite resin Filtek Z350 (3M) and Filtek P60(3M) on culture medium for 24 hours. The cell proliferation of the tooth-colored restorative materials on human macrophages in vitro was evaluated by MTT color imetric assay, and determined for IL-1 content in these material specimens by ELISA. All statistical analyses were performed using the SPSS 17.0 software package. RESULTS: Compared with control group, composite resin Filtek Z350(3M) and Filtek P60(3M) significantly enhanced the proliferation of human macrophages (P<0.05), while Glass-ionomer had little effect on the proliferation of human macrophages (P>0.05). Glass-ionomer could promote macrophages to secrete IL-1β and the difference was statistically significant(P<0.05). The composite resin could not cause release of IL-1β from macrophages (P>0.05). CONCLUSIONS:
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Authors | Yu Gong, Rong-qiang Yang, Hong-li Yang |
Journal | Shanghai kou qiang yi xue = Shanghai journal of stomatology
(Shanghai Kou Qiang Yi Xue)
Vol. 22
Issue 4
Pg. 414-7
(Aug 2013)
ISSN: 1006-7248 [Print] China |
PMID | 24100900
(Publication Type: Journal Article)
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Chemical References |
- Acrylic Resins
- Composite Resins
- Dental Materials
- Glass Ionomer Cements
- filtek Z350
- glass ionomer
- Silicon Dioxide
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Topics |
- Acrylic Resins
- Cell Proliferation
- Composite Resins
- Dental Materials
- Dentin
- Glass Ionomer Cements
- Humans
- Macrophages
- Silicon Dioxide
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