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[Effects of composite resin and glass-ionomer cements on proliferation and functional activity of human macrophages].

AbstractPURPOSE:
To study the effects of composite resin and glass-ionomer cements on cell proliferation and function of human macrophages in vitro.
METHODS:
Macrophages were differentiated from THP-1 cells after treatment with phorbol ester and used as the model of inflammatory cells, which were treated by specimens from glass-ionomer cements(GC), composite resin Filtek Z350 (3M) and Filtek P60(3M) on culture medium for 24 hours. The cell proliferation of the tooth-colored restorative materials on human macrophages in vitro was evaluated by MTT color imetric assay, and determined for IL-1 content in these material specimens by ELISA. All statistical analyses were performed using the SPSS 17.0 software package.
RESULTS:
Compared with control group, composite resin Filtek Z350(3M) and Filtek P60(3M) significantly enhanced the proliferation of human macrophages (P<0.05), while Glass-ionomer had little effect on the proliferation of human macrophages (P>0.05). Glass-ionomer could promote macrophages to secrete IL-1β and the difference was statistically significant(P<0.05). The composite resin could not cause release of IL-1β from macrophages (P>0.05).
CONCLUSIONS:
Composite resin enhances proliferation and function of human macrophages. The effect may be associated with hypersensitivity of dentin. Glass-ionomer cement has little effect on proliferation of macrophages, but may lead to progress of inflammation.
AuthorsYu Gong, Rong-qiang Yang, Hong-li Yang
JournalShanghai kou qiang yi xue = Shanghai journal of stomatology (Shanghai Kou Qiang Yi Xue) Vol. 22 Issue 4 Pg. 414-7 (Aug 2013) ISSN: 1006-7248 [Print] China
PMID24100900 (Publication Type: Journal Article)
Chemical References
  • Acrylic Resins
  • Composite Resins
  • Dental Materials
  • Glass Ionomer Cements
  • filtek Z350
  • glass ionomer
  • Silicon Dioxide
Topics
  • Acrylic Resins
  • Cell Proliferation
  • Composite Resins
  • Dental Materials
  • Dentin
  • Glass Ionomer Cements
  • Humans
  • Macrophages
  • Silicon Dioxide

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