[Cathepsin L cysteine protease from Taenia solium: its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis].

Abstract

Taenia solium is a plane helminth responsible for taeniasis and human cysticercosis, the latter being the result of the consumption of infective eggs. Cysticerci can develop in different human tissues, often in the central nervous system, causing neurocysticercosis (NCC). For the diagnosis of NCC, an adequate interpretation of clinical data, neuroimaging results and serological tests are required. However, serological tests could be improved by developing candidate antigens able to increase their sensibility and specificity. In the last years, a series of surface and secretory proteins of T. solium essential for the parasite-host interaction have been described. One of these families is cathepsin L cysteine proteases, which have a predominant role in the development and survival of the parasite. They take part in the tissue invasion, immune response evasion, excystation and encystment of cysticercus. They are considered potential antigens for the immunodiagnosis of neurocysticercosis.

• Authors: Nancy León, Carlos Padilla, Mónica Pajuelo, Patricia Sheen, Mirko Zimic
• Journal: Revista peruana de medicina experimental y salud publica (Rev Peru Med Exp Salud Publica) Vol. 30 Issue 3 Pg. 446-54 (Jul 2013) ISSN: 1726-4642 [Electronic] Peru
• Vernacular Title: Cisteínoproteasas catepsinas L de Taenia solium: rol biológico en la infección y potencial uso para el inmunodiagnóstico de la neurocisticercosis.
• PMID: 24100821 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Cathepsin L

Topics

• Animals
• Cathepsin L (analysis, physiology)
• Humans
• Immunologic Tests
• Neurocysticercosis (diagnosis, immunology)
• Taenia solium (enzymology, immunology, pathogenicity)