The safety and efficacy of thalamic deep brain stimulation in essential tremor: 10 years and beyond.

Abstract

BACKGROUND:

Deep brain stimulation (DBS) has proven to be a safe and effective therapy for refractory essential tremor, but information regarding long-term outcomes is lacking.

OBJECTIVES:

We aimed to assess the long-term safety and efficacy of DBS in patients with essential tremor.

METHODS:

Patients treated with DBS for essential tremor for at least 8 years were evaluated in the 'on' and 'off' state using the Fahn-Tolosa-Marin tremor rating scale, and their medical records were reviewed to assess complications related to this therapy.

RESULTS:

We studied 13 patients (7 men): median age at evaluation 79 years (range 47-88), median age at electrode implantation 68 years (range 37-78) and mean time since electrode implantation 132.54±15.3 months (range 114-164). The difference between the 'off' and 'on' state on the motor items of the tremor rating scale was 41.9% (58.62 vs. 34.08, p<0.001) in the non-blinded and 37.2% (56.07 vs. 35.23, p<0.001) in the blinded rating. DBS provided a functional improvement of 31.7% in the 'on' state (15.07 vs. 22.07, p<0.001). A total non-blinded improvement in the tremor rating scale of 39% was observed in the 'on' state (49.15 vs. 80.69, p<0.001). Dysarthria and disequilibrium were common in patients with bilateral stimulation. A DBS-related surgery (electrode revision or internal pulse generator exchange) was necessary on average every 47.9 months to continue with the DBS therapy.

CONCLUSIONS:

Thalamic DBS is a safe and effective therapy in patients with essential tremor followed for up to 13 years.

• Authors: José Fidel Baizabal-Carvallo, Melissa N Kagnoff, Joohi Jimenez-Shahed, Robert Fekete, Joseph Jankovic
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 85 Issue 5 Pg. 567-72 (May 2014) ISSN: 1468-330X [Electronic] England
• PMID: 24096713 (Publication Type: Journal Article)

Topics

• Aged
• Aged, 80 and over
• Deep Brain Stimulation
• Dysarthria (etiology, physiopathology, prevention & control)
• Essential Tremor (complications, physiopathology, therapy)
• Female
• Follow-Up Studies
• Gait Disorders, Neurologic (etiology, physiopathology, prevention & control)
• Humans
• Male
• Middle Aged
• Thalamus
• Time Factors
• Treatment Outcome