High risk human papillomavirus at entry to prenatal care and risk of preeclampsia.

Abstract

OBJECTIVE:

To determine the association between high-risk human papillomavirus (HR-HPV) and preeclampsia.

METHODS:

Retrospective cohort study of women with HR-HPV at entry to prenatal care compared with those with at least 2 normal pap smears. Preeclampsia was defined by clinical guidelines. Unadjusted and adjusted analyses were performed.

RESULTS:

Three hundred fourteen women with HR-HPV matched with 628 women with normal pap smears. Exposed HR-HPV patients were younger, had lower body mass index, systolic and diastolic blood pressure at entry to care, and more likely to be nulliparous and smokers. Exposed HR-HPV patients were more likely to develop preeclampsia (10.19% vs 4.94%; P = .004; adjusted odds ratio, 2.18; 95% confidence interval, 1.31-3.65). Women with HR-HPV were also more likely to deliver prematurely at less than 37 and less than 35 weeks.

CONCLUSION:

HR-HPV is associated with an almost 2-fold increased risk of developing preeclampsia. This warrants a larger study, particularly when HPV infection can be prevented with vaccination.

• Authors: Mollie McDonnold, Holly Dunn, Ashley Hester, Luis D Pacheco, Gary D V Hankins, George R Saade, Maged M Costantine
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 210 Issue 2 Pg. 138.e1-5 (Feb 2014) ISSN: 1097-6868 [Electronic] United States
• PMID: 24096182 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Mosby, Inc. All rights reserved.

Topics

• Adult
• Age Factors
• Female
• Humans
• Papillomavirus Infections (complications)
• Parity
• Pre-Eclampsia (etiology)
• Pregnancy
• Pregnancy Complications, Infectious
• Prenatal Care
• Retrospective Studies
• Risk Factors
• Smoking (adverse effects)