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Clinically-driven need for secondary interventions after endovascular revascularization of tibial arteries in patients with critical limb ischemia.

AbstractPURPOSE:
To assess the need for clinically-driven secondary revascularization in critical limb ischemia (CLI) patients subsequent to tibial angioplasty during a 2-year follow-up.
METHODS:
Between 2008 and 2010, a total of 128 consecutive CLI patients (80 men; mean age 76.5±9.8 years) underwent tibial angioplasty in 139 limbs. Rutherford categories, ankle-brachial index measurements, and lower limb oscillometries were prospectively assessed. All patients were followed at 3, 6, 12 months, and annually thereafter. Rates of death, primary and secondary sustained clinical improvement, target lesion (TLR) and target extremity revascularization (TER), as well as major amputation, were analyzed retrospectively. Primary clinical improvement was defined as improvement in Rutherford category to a level of intermittent claudication without unplanned amputation or TLR.
RESULTS:
All-cause mortality was 8.6%, 14.8%, 22.9%, and 29.1% at 3, 6, 12, and 24 months. At the same intervals, rates of primary sustained clinical improvement were 74.5%, 53.0%, 42.7%, and 37.1%; for secondary improvement, the rates were 89.1%, 76.0%, 68.4%, and 65.0%. Clinically-driven TLR rates were 14.6%, 29.1%, 41.6%, 46.2%; the rates for TER were 3.0%, 13.6%, 17.2%, and 27.6% in corresponding intervals, while the rates of major amputation were 1.5%, 5.5%, 10.1%, and 10.1%.
CONCLUSION:
Clinically-driven TLR is frequently required to maintain favorable functional clinical outcomes in CLI patients following tibial angioplasty. Dedicated technologies addressing tibial arterial restenosis warrant further academic scrutiny.
AuthorsFrederic Baumann, Stephan Bloesch, Rolf Peter Engelberger, Vladimir Makaloski, Hanspeter Fink, Dai-Do Do, Iris Baumgartner, Nicolas Diehm
JournalJournal of endovascular therapy : an official journal of the International Society of Endovascular Specialists (J Endovasc Ther) Vol. 20 Issue 5 Pg. 707-13 (Oct 2013) ISSN: 1545-1550 [Electronic] United States
PMID24093325 (Publication Type: Journal Article)
Topics
  • Aged
  • Aged, 80 and over
  • Amputation, Surgical
  • Angioplasty, Balloon (adverse effects, mortality)
  • Critical Illness
  • Female
  • Humans
  • Ischemia (diagnosis, mortality, therapy)
  • Kaplan-Meier Estimate
  • Limb Salvage
  • Lower Extremity (blood supply)
  • Male
  • Proportional Hazards Models
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Tibial Arteries
  • Time Factors
  • Treatment Outcome

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