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Anti-glutamic Acid decarboxylase antibody associated limbic encephalitis in a child: expanding the spectrum of pediatric inflammatory brain diseases.

Abstract
Anti-glutamic acid decarboxylase directed antibodies are a rare cause of autoimmune limbic encephalitis that is relatively resistant to immunotherapy. Here we report a 15-year-old boy with nonparaneoplastic, anti-glutamic acid decarboxylase limbic encephalitis presenting with subacute headache, memory disturbance, psychiatric symptoms, and seizures. At onset, his memory disturbance manifested as transient global amnesia-like episodes. Clinical remission was achieved with rituximab, intravenous immunoglobulin, and corticosteroids.
AuthorsNavin Mishra, Lance H Rodan, Dragos A Nita, Nuria Gresa-Arribas, Jeff Kobayashi, Susanne M Benseler
JournalJournal of child neurology (J Child Neurol) Vol. 29 Issue 5 Pg. 677-83 (May 2014) ISSN: 1708-8283 [Electronic] United States
PMID24092895 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies
  • Glutamate Decarboxylase
Topics
  • Adolescent
  • Antibodies (blood)
  • Autoimmune Diseases (blood, immunology, physiopathology)
  • Electroencephalography
  • Glutamate Decarboxylase (immunology)
  • Humans
  • Limbic Encephalitis (blood, immunology, physiopathology)
  • Magnetic Resonance Imaging
  • Male

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