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Quinine-induced severe thrombocytopenia: the importance of taking a detailed drug history.

Abstract
Drugs can lead to severe life-threatening thrombocytopenia. The mechanisms of drug-induced thrombocytopenia are increased destruction by immune-mediated platelet destruction or decreased platelet production by bone marrow suppression. Quinine is a drug used for the treatment of malaria and nocturnal leg cramps and is also an important ingredient in some herbal preparations. Quinine can very rarely cause thrombocytopenia by immune-mediated platelet destruction. In a patient with thrombocytopenia, a detailed history of all the medications including over-the-counter medications and herbal preparations is very important.
AuthorsMuhajir Mohamed, Robert Hayes
JournalBMJ case reports (BMJ Case Rep) Vol. 2013 (Oct 03 2013) ISSN: 1757-790X [Electronic] England
PMID24092609 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Glucocorticoids
  • Muscle Relaxants, Central
  • Prednisolone
  • Quinine
Topics
  • Aged
  • Diagnosis, Differential
  • Female
  • Glucocorticoids (therapeutic use)
  • Humans
  • Medical History Taking
  • Muscle Cramp (drug therapy)
  • Muscle Relaxants, Central (adverse effects)
  • Prednisolone (therapeutic use)
  • Quinine (adverse effects)
  • Thrombocytopenia (chemically induced, diagnosis, drug therapy)

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