Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.

Abstract

BACKGROUND AND PURPOSE:

Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether FXI gene (F11) variants are associated with ischemic stroke.

METHODS:

The discovery sample, the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), included 844 patients with ischemic stroke and 668 controls, all aged 18-70 years. Replication was performed in the Lund Stroke Register (LSR) and Malmö Diet and Cancer study (MDC), together including 1213 patients and 788 controls up to 70 years of age, and in total 3145 patients and 1793 controls (18-102 years). Seven F11 single-nucleotide polymorphisms (SNPs) were selected using a tagging approach.

RESULTS:

The SNPs rs3733403, rs925451, and rs1593 showed independent associations with overall ischemic stroke in SAHLSIS, ORs of 0.74 (95% CI 0.59-0.94), 1.24 (95% CI 1.06-1.46), and 0.70 (95% CI 0.55-0.90), respectively. The association for rs925451 was replicated in the LSR and MDC sample in a pre-specified analysis of subjects aged 70 years or younger, OR of 1.16 (95% CI 1.00-1.34), whereas no SNP was replicated when all ages were included. In line with this, one F11 haplotype was associated with overall ischemic stroke in the discovery sample and in the replication sample ≤70 years.

CONCLUSIONS:

We found significant associations between F11 variation and overall ischemic stroke up to 70 years of age. These findings motivate further studies on the role of F11 in ischemic stroke, especially in younger individuals.

• Authors: Ellen Hanson, Staffan Nilsson, Katarina Jood, Bo Norrving, Gunnar Engström, Christian Blomstrand, Arne Lindgren, Olle Melander, Christina Jern
• Journal: PloS one (PLoS One) Vol. 8 Issue 9 Pg. e75286 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 24086496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Factor XI

Topics

• Adult
• Age Factors
• Aged
• Factor XI (genetics)
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Genetic Variation (genetics)
• Genotype
• Humans
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Stroke (genetics)
• Sweden