Abstract | BACKGROUND: MATERIALS AND METHODS: On day 14 of gestation, female Sprague-Dawley rats were separated into five groups and treated intravenously for 7 days as follows: (i) 0.3 mL 0.9% saline (control, n = 11); (ii) 50 mg/kg Body Weight (BW) N-nitro- L-arginine methyl ester ( L-NAME) in 0.3 mL saline (n = 10); (iii) 50 mg/kg BW L-NAME and 8 mg/kg BW GSNO in 0.15 mL saline (n = 6); (iv) 50 mg/kg BW L-NAME in 0.15 mL saline and 8 mg/kg BW SNAP in 0.15 mL DMSO (n = 9); and (v) 0.15 mL DMSO and 0.15 mL saline (SNAP control, n = 7). Blood pressures were measured on day 14 through day 20, a 4-h urine sample was taken on day 20, and animals were sacrificed on day 21. Pups were counted and weighed individually. RESULTS: SNAP and GSNO significantly decreased systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20 (P < 0.05). Pup weights in SNAP and GSNO groups were higher than in L-NAME group but lower than in controls (P ≤ 0.001). SNAP and GSNO partially reversed growth retardation. CONCLUSION:
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Authors | Caneta Brown, Norma McFarlane-Anderson, Ruby Alexander-Lindo, Karen Bishop, Tara Dasgupta, Donovan McGrowder |
Journal | Journal of natural science, biology, and medicine
(J Nat Sci Biol Med)
Vol. 4
Issue 2
Pg. 330-5
(Jul 2013)
ISSN: 0976-9668 [Print] India |
PMID | 24082727
(Publication Type: Journal Article)
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