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Restoring ionotropic inhibition as an analgesic strategy.

Abstract
Neuronal inhibition in nociceptive relays of the spinal cord is essential for the proper processing of nociceptive information. In the spinal cord dorsal horn, the activity of synaptic and extrasynaptic GABAA and glycine receptors generates rapid, Cl(-)-dependent neuronal inhibition. A loss of this ionotropic inhibition, particularly through the collapse of the inhibitory Cl(-)-gradient, is a key mechanism by which pathological pain conditions develop. This review summarizes the roles of ionotropic inhibition in the regulation of nociception, and explores recent evidence that the potentiation of GABAA or glycine receptor activity or the enhancement of inhibitory drive can reverse pathological pain.
AuthorsRobert P Bonin, Yves De Koninck
JournalNeuroscience letters (Neurosci Lett) Vol. 557 Pt A Pg. 43-51 (Dec 17 2013) ISSN: 1872-7972 [Electronic] Ireland
PMID24080373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Analgesics
  • Brain-Derived Neurotrophic Factor
  • Receptors, GABA-A
  • Receptors, Glycine
  • Symporters
  • potassium-chloride symporters
Topics
  • Analgesics (therapeutic use)
  • Animals
  • Brain-Derived Neurotrophic Factor (metabolism)
  • Humans
  • Microglia (physiology)
  • Neural Inhibition (drug effects, physiology)
  • Nociception (physiology)
  • Pain (drug therapy, metabolism)
  • Receptors, GABA-A (metabolism)
  • Receptors, Glycine (metabolism)
  • Symporters (metabolism)

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