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Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia.

Abstract
Alveolar capillary dysplasia (ACD) with misalignment of pulmonary veins (MPV) is a lethal neonatal lung disease. Death from ACD/MPV is caused by hypoxia, but the role of the MPV is unknown. Using 3-dimensional reconstruction of ACD/MPV lung tissue, we report that the veins in MPV are intrapulmonary shunt vessels, and speculate that MPV contributes to the poor prognosis.
AuthorsCsaba Galambos, Sunder Sims-Lucas, Steven H Abman
JournalThe Journal of pediatrics (J Pediatr) Vol. 164 Issue 1 Pg. 192-5 (Jan 2014) ISSN: 1097-6833 [Electronic] United States
PMID24079727 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2014 Mosby, Inc. All rights reserved.
Topics
  • Cadaver
  • Diagnosis, Differential
  • Humans
  • Imaging, Three-Dimensional (methods)
  • Immunohistochemistry (methods)
  • Infant, Newborn
  • Lung (blood supply)
  • Persistent Fetal Circulation Syndrome (diagnosis)
  • Pulmonary Alveoli (abnormalities)
  • Pulmonary Veins (pathology)
  • Reproducibility of Results

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