Drug-related nail disease.

Abstract

Drug-induced nail abnormalities can present with a wide variety of clinical manifestations that are often dose-related and that disappear after drug withdrawal. Some nail changes are asymptomatic and only cause cosmetic problems, whereas others cause pain and discomfort and impair manual activities or deambulation. New side effects have been recently observed with different groups of anticancer agents. These include painful onycholysis and subungual abscesses caused by taxanes and anthracyclines (eg, doxorubicin) in addition to ingrown nails, paronychia, and pyogenic granuloma associated with the use of tyrosine kinase inhibitors of the epidermal growth factor receptor (eg, erlotinib, gefitinib).

• Authors: Bianca Maria Piraccini, Aurora Alessandrini
• Journal: Clinics in dermatology (Clin Dermatol) 2013 Sep-Oct Vol. 31 Issue 5 Pg. 618-26 ISSN: 1879-1131 [Electronic] United States
• PMID: 24079591 (Publication Type: Journal Article)
• Copyright: © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors

Topics

• Antineoplastic Agents (adverse effects)
• Drug Eruptions (etiology)
• Fingers
• Granuloma, Pyogenic (chemically induced)
• Hemorrhage (chemically induced)
• Humans
• Hyperpigmentation (chemically induced)
• Hypopigmentation (chemically induced)
• Nail Diseases (chemically induced)
• Onycholysis (chemically induced)
• Paronychia (chemically induced)
• Protein Kinase Inhibitors (adverse effects)
• Toes