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Etiology and incidence of pediatric gallbladder disease.

AbstractPURPOSE:
The spectrum of pediatric biliary tract disease is changing. The goal of this study was to examine the causes and comorbidities of pediatric gallbladder disease at our institution.
METHODS:
We performed a retrospective chart review on consecutive patient at Kosair Children's Hospital who underwent cholecystectomy over a 9-year time period ending in 2012.
RESULTS:
Among the 453 patients in the study group, the average age was 13.3 years and 67.2% were female. Indications for cholecystectomy were gallstones in 285 (63%) and biliary dyskinesia in 140 (33%). Of the patients with gallstones, 68 children (15%) had hemolytic disease. Although the number of cholecystectomies for hemolytic disease was relatively stable throughout our study, the number for biliary dyskinesia and non-hemolytic (cholesterol) cholelithiasis rose by 63% and 216%, respectively. Average body mass index (BMI) for patients with non-hemolytic (cholesterol) stones and biliary dyskinesia were significantly greater than the average BMI for patients with hemolytic stones (P < .0001). In addition, the average BMI for children with non-hemolytic (cholesterol) stones was greater than the average BMI with biliary dyskinesia (P < .0001).
CONCLUSION:
Symptomatic gallbladder disease increased over the study period. Biliary dyskinesia and children with non-hemolytic disease are responsible for this increase.
AuthorsSarah K Walker, Alexandra C Maki, Robert M Cannon, David S Foley, Kristina M Wilson, Laura A Galganski, Chad A Wiesenauer, Sheldon J Bond
JournalSurgery (Surgery) Vol. 154 Issue 4 Pg. 927-31; discussion 931-3 (Oct 2013) ISSN: 1532-7361 [Electronic] United States
PMID24074432 (Publication Type: Journal Article)
CopyrightCopyright © 2013 Mosby, Inc. All rights reserved.
Chemical References
  • Imino Acids
  • iminodiacetic acid
Topics
  • Adolescent
  • Body Mass Index
  • Child
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholecystectomy
  • Female
  • Gallbladder Diseases (epidemiology, etiology, surgery)
  • Humans
  • Imino Acids
  • Incidence
  • Male
  • Retrospective Studies

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