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Tumoral FOXP3 has potential oncogenic function in conjunction with the p53 tumor suppressor protein and infiltrated Tregs in human breast carcinomas.

Abstract
FOXP3 is a transcription factor and a well-known hallmark of immune suppressive T regulatory cells. Recent studies indicate that in tumor cells, FOXP3 plays an important role in tumor development in addition to its well-established Treg function in the immune system. We investigated tumoral FOXP3 expression in breast carcinoma, and the relationships between tumoral FOXP3 expression and p53, HER-2/ErbB2, Ki67, infiltrated Tregs, and other clinicopathological variables. Tissue samples from 272 cases of breast carcinoma were used. We assessed tumoral FOXP3, p53, HER-2/ErbB2, Ki67, and infiltrated Tregs using immunohistochemical staining. Positive expression of tumoral FOXP3 was observed in 38.6% (105/272) of breast carcinomas. Positive tumoral FOXP3 expression was significantly related with positive p53 and higher Ki67 expression. Higher histological grade was significantly correlated to increased tumoral FOXP3 expression. Tumoral FOXP3 expression was positively correlated with infiltrated FOXP3-expressing Tregs. From these data, we argue that tumoral FOXP3 has a potential oncogenic function in conjunction with the p53 tumor suppressor protein and infiltrated Tregs in human breast carcinomas.
AuthorsKyu Yeoun Won, Hyun-Soo Kim, Ji-Youn Sung, Gou Young Kim, Juhie Lee, Yong-Koo Park, Youn Wha Kim, Jung-Ho Suh, Sung-Jig Lim
JournalPathology, research and practice (Pathol Res Pract) Vol. 209 Issue 12 Pg. 767-73 (Dec 2013) ISSN: 1618-0631 [Electronic] Germany
PMID24071443 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier GmbH. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Tumor Suppressor Protein p53
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (metabolism)
  • Breast Neoplasms (immunology, metabolism, pathology)
  • Carcinoma (immunology, metabolism, pathology)
  • Female
  • Forkhead Transcription Factors (metabolism)
  • Humans
  • Middle Aged
  • Prognosis
  • T-Lymphocytes, Regulatory (immunology, metabolism, pathology)
  • Tumor Suppressor Protein p53 (metabolism)

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