Mycophenolic acid for lymphomatoid papulosis.

Abstract

BACKGROUND:

Lymphomatoid papulosis is a rare CD30+ lymphoproliferative T-cell disorder with limited effective treatments.

OBJECTIVE:

We describe the case of a 50-year-old woman diagnosed with lymphomatoid papulosis who was unable to access phototherapy and who failed to clear while on systemic treatment with methotrexate.

METHODS:

The patient was initiated on mycophenolate mofetil (MMF), a prodrug of mycophenolic acid, at a dose of 2 g divided twice daily.

RESULTS:

MMF produced a rapid response with complete clearing within 8 weeks, and the patient has been successfully maintained for 2 years at the same dose with no noted side effects. Other patients in our clinic have had similar success.

CONCLUSIONS:

Mycophenolic acid is a safe and well-tolerated therapy for lymphomatoid papulosis.

• Authors: Trevor Champagne, Scott Walsh
• Journal: Journal of cutaneous medicine and surgery (J Cutan Med Surg) 2013 Sep-Oct Vol. 17 Issue 5 Pg. 332-4 ISSN: 1203-4754 [Print] United States
• PMID: 24067853 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Mycophenolic Acid

Topics

• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Lymphomatoid Papulosis (drug therapy, pathology)
• Middle Aged
• Mycophenolic Acid (analogs & derivatives, therapeutic use)
• Skin Neoplasms (drug therapy)