Abstract | BACKGROUND: METHODS: RESULTS:
Lymph node metastasis of gastric cancer was related with tumor location, Bormann type, tumor size, histological type, depth of invasion and TNM stage (p < 0.05). The values of CA724, CA242, CA199 and CEA were positively correlated with the metastatic lymph node counts and the N stage (p < 0.05). The later the N stage was, the levels of CA724, CA242 and CA199 were higher. The later the N stage was, the positive rates of tumor markers were higher (p < 0.05). In comparing with single tumor markers, the positive rates of tumor markers combination were higher. The combination of CA724 + CA242 + CA199 + CEA had highest positive rate. The higher CEA level related to N1 stage patients while higher CA199 was related with poor prognosis for N1 stage patients. For N0 and N2 stage patients, evaluation of CA724 indicated poorer prognosis. For N1 and N2 stage gastric patients, the patients with increased CA242 inclined to have shorter survival time. CONCLUSIONS:
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Authors | Fangxuan Li, Shixia Li, Lijuan Wei, Xiaofeng Liang, Huan Zhang, Juntian Liu |
Journal | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
(Biomarkers)
Vol. 18
Issue 7
Pg. 632-7
(Nov 2013)
ISSN: 1366-5804 [Electronic] England |
PMID | 24066812
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Tumor-Associated, Carbohydrate
- CA 242 antigen
- CA-72-4 antigen
- Carcinoembryonic Antigen
- carbohydrate antigen 199, human
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Topics |
- Adenocarcinoma
(blood, mortality, secondary, therapy)
- Aged
- Antigens, Tumor-Associated, Carbohydrate
(blood)
- Carcinoembryonic Antigen
(blood)
- Female
- Humans
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Stomach Neoplasms
(blood, mortality, pathology, therapy)
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