Abstract | BACKGROUND AND OBJECTIVES: METHODS: After a systematic literature review and selection of English language studies, sensitivity, specificity and other measures of accuracy of Cyfra 21-1 in the diagnosis of head and neck squamous cell carcinoma were pooled using random effects models. Summary receiver operating characteristic curve was used to summarize overall diagnostic performance. Publication bias was examined by Deeks' funnel plot. RESULTS: Thirteen studies with 2269 subjects met the inclusion criteria for the analysis. The pooled sensitivity and specificity of Cyfra 21-1 for diagnosing head and neck squamous cell carcinoma were 0.51 (95%CI: 0.48-0.54) and 0.97 (95%CI: 0.95-0.98), respectively. The positive likelihood ratio was 10.11 (95%CI: 6.50-15.71), negative likelihood ratio was 0.52 (95%CI: 0.41-0.66) and diagnostic odds ratio was 25.60 (95%CI: 13.39-48.96). The area under the summary receiver operating characteristic curve was 0.94. CONCLUSIONS:
|
Authors | Y-X Wang, D Hu, X Yan |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 17
Issue 17
Pg. 2383-9
(Sep 2013)
ISSN: 1128-3602 [Print] Italy |
PMID | 24065233
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Keratin-19
- antigen CYFRA21.1
|
Topics |
- Antigens, Neoplasm
(blood)
- Biomarkers, Tumor
(blood)
- Head and Neck Neoplasms
(diagnosis, pathology)
- Humans
- Keratin-19
(blood)
- Neoplasms, Squamous Cell
(diagnosis, pathology)
- ROC Curve
- Sensitivity and Specificity
|