HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Proteomic biomarkers for spontaneous preterm birth: a systematic review of the literature.

Abstract
This review aimed to identify, synthesize, and analyze the findings of studies on proteomic biomarkers for spontaneous preterm birth (PTB). Three electronic databases (Medline, Embase, and Scopus) were searched for studies in any language reporting the use of proteomic biomarkers for PTB published between January 1994 and December 2012. Retrieved citations were screened, and relevant studies were selected for full-text reading, in triplicate. The search yielded 529 citations, 51 were selected for full-text reading and 8 studies were included in the review. A total of 64 dysregulated proteins were reported. Only 14-3-3 protein sigma, annexin A5, protein S100-A8, protein S100-A12, and inter-α-trypsin inhibitor heavy chain H4 were reported in more than 1 study, but results could not be combined due to heterogeneity in type of sample and analytical platform. In conclusion, according to the existing literature, there are no specific proteomic biomarkers capable of accurately predicting PTB.
AuthorsMarian Kacerovsky, Juraj Lenco, Ivana Musilova, Vojtech Tambor, Ronald Lamont, Maria Regina Torloni, Ramkumar Menon, PREBIC Biomarker Working Group 2012-2013
JournalReproductive sciences (Thousand Oaks, Calif.) (Reprod Sci) Vol. 21 Issue 3 Pg. 283-95 (Mar 2014) ISSN: 1933-7205 [Electronic] United States
PMID24060632 (Publication Type: Journal Article, Review, Systematic Review)
Chemical References
  • Biomarkers
Topics
  • Biomarkers (blood, metabolism)
  • Female
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Premature Birth (diagnosis, metabolism)
  • Proteomics (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: