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Interleukin-6 polymorphisms and hematologic malignancy: a re-appraisal of evidence from genetic association studies.

AbstractCONTEXT:
Interleukin-6 (IL-6) is implicated in the pathophysiology of hematologic neoplasia.
OBJECTIVE:
To review the role of IL-6 single nucleotide polymorphisms (SNPs) in hematologic neoplasia.
METHODS:
PubMed and EMBASE search of genetic association studies. Effects were summarized using the model-free generalized odds ratio (ORG), and the mode of inheritance was estimated for significant associations.
RESULTS:
Seventeen articles provided data on 20 distinct SNPs. The IL-6 receptor rs8192284 was associated with an increased risk of hematologic malignancy (combined ORG 1.42, 95%CI 1.03-1.96), including multiple myeloma (ORG 1.39, 95%CI 0.99-1.95). The IL-6 promoter rs1800795 conferred protection against young adult Hodgkin's disease (ORG 0.68, 95%CI 0.48-0.95). Significant single-study effects for four other SNPs-disease associations were estimated. The IL-6 promoter rs1800795 and rs1800797 were not associated with overall susceptibility to non-Hodgkin's lymphomas.
CONCLUSIONS:
There is accumulating evidence that the IL-6 promoter, receptor and signal transducer SNPs can modify disease susceptibility.
AuthorsPanayiotis D Ziakas, Petros Karsaliakos, Michael L Prodromou, Eleftherios Mylonakis
JournalBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 18 Issue 7 Pg. 625-31 (Nov 2013) ISSN: 1366-5804 [Electronic] England
PMID24059848 (Publication Type: Journal Article, Meta-Analysis)
Chemical References
  • IL6 protein, human
  • Interleukin-6
Topics
  • Case-Control Studies
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-6 (genetics)
  • Lymphoma (genetics)
  • Multiple Myeloma (genetics)
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Risk

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