Abstract | CONTEXT: OBJECTIVE: To review the role of IL-6 single nucleotide polymorphisms (SNPs) in hematologic neoplasia. METHODS: PubMed and EMBASE search of genetic association studies. Effects were summarized using the model-free generalized odds ratio (ORG), and the mode of inheritance was estimated for significant associations. RESULTS: Seventeen articles provided data on 20 distinct SNPs. The IL-6 receptor rs8192284 was associated with an increased risk of hematologic malignancy (combined ORG 1.42, 95%CI 1.03-1.96), including multiple myeloma (ORG 1.39, 95%CI 0.99-1.95). The IL-6 promoter rs1800795 conferred protection against young adult Hodgkin's disease (ORG 0.68, 95%CI 0.48-0.95). Significant single-study effects for four other SNPs-disease associations were estimated. The IL-6 promoter rs1800795 and rs1800797 were not associated with overall susceptibility to non-Hodgkin's lymphomas. CONCLUSIONS:
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Authors | Panayiotis D Ziakas, Petros Karsaliakos, Michael L Prodromou, Eleftherios Mylonakis |
Journal | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
(Biomarkers)
Vol. 18
Issue 7
Pg. 625-31
(Nov 2013)
ISSN: 1366-5804 [Electronic] England |
PMID | 24059848
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- IL6 protein, human
- Interleukin-6
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Topics |
- Case-Control Studies
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Interleukin-6
(genetics)
- Lymphoma
(genetics)
- Multiple Myeloma
(genetics)
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Risk
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