Abstract | PURPOSE: METHODS: RESULTS: Eighteen of the 90 episodes were classified as bacteremia/clinical sepsis. On both days 1 and 2, all biomarkers had a low to intermediate diagnostic accuracy for sepsis, and no significant differences were found between them (area under the curve (AUC) for LBP, 0.648 and 0.714; for PCT, 0.665 and 0.744; for IL-6, 0.775 and 0.775; and for CRP, 0.695 and 0.828). Comparison of their AUCs to the AUC of maximum body temperature on admission (AUC = 0.668) also failed to show any significant differences. In severe sepsis, however, the best diagnostic accuracies were found for IL-6 and PCT (AUC 0.892 and 0.752, respectively), and these were significantly higher than those for LBP (AUC 0.566) on admission. CONCLUSIONS: On admission and 24 h later, the LBP concentration is less accurate for predicting bacteremia/clinical sepsis compared to IL-6, PCT, and CRP.
|
Authors | Lidija Kitanovski, Janez Jazbec, Sergej Hojker, Metka Derganc |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 22
Issue 1
Pg. 269-77
(Jan 2014)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 24057110
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Acute-Phase Proteins
- Biomarkers
- CALCA protein, human
- Carrier Proteins
- Interleukin-6
- Membrane Glycoproteins
- Protein Precursors
- lipopolysaccharide-binding protein
- Calcitonin
- C-Reactive Protein
- Calcitonin Gene-Related Peptide
|
Topics |
- Acute-Phase Proteins
- Bacteremia
(blood)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Calcitonin
(blood)
- Calcitonin Gene-Related Peptide
- Carrier Proteins
(blood)
- Child
- Child, Preschool
- Febrile Neutropenia
(blood, microbiology)
- Female
- Humans
- Infant
- Interleukin-6
(blood)
- Male
- Membrane Glycoproteins
(blood)
- Predictive Value of Tests
- Prospective Studies
- Protein Precursors
(blood)
|