Abstract |
A boy with Pelizaeus-Merzbacher disease underwent repeated evaluations by 3-Tesla (1)H-magnetic resonance spectroscopy (MRS). The patient showed overlap of the PLP1. Individuals selected as normal controls for (1)H-magnetic resonance spectroscopy consisted of healthy age-matched children. For (1)H-magnetic resonance spectroscopy, the center of a voxel was positioned in the right parietal lobe. (1)H-magnetic resonance spectroscopy was performed when the patient was 2, 6, 14, and 25 months old. γ- Aminobutyric acid concentration in early childhood was increased compared with that in normal controls. However, the γ- aminobutyric acid concentration in the Pelizaeus-Merzbacher disease patient was normalized at 14 and 25 months. No remarkable changes were observed in choline-containing compounds concentration at any time. These results suggest that the changes in metabolite concentrations during growth can reflect the pathological condition of Pelizaeus-Merzbacher disease. Furthermore, the lack of change in the choline-containing compounds concentration can be useful for differentiating Pelizaeus-Merzbacher disease from other white matter disorders.
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Authors | Tatsuo Mori, Kenji Mori, Hiromichi Ito, Aya Goji, Masahito Miyazaki, Masafumi Harada, Kenji Kurosawa, Shoji Kagami |
Journal | Journal of child neurology
(J Child Neurol)
Vol. 29
Issue 2
Pg. 283-8
(Feb 2014)
ISSN: 1708-8283 [Electronic] United States |
PMID | 24056155
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Aspartic Acid
- Glutamic Acid
- Inositol
- gamma-Aminobutyric Acid
- N-acetylaspartate
- Creatine
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Topics |
- Aging
- Aspartic Acid
(analogs & derivatives, metabolism)
- Case-Control Studies
- Child, Preschool
- Creatine
(metabolism)
- Glutamic Acid
(metabolism)
- Humans
- Infant
- Inositol
(metabolism)
- Magnetic Resonance Spectroscopy
- Male
- Parietal Lobe
(growth & development, metabolism)
- Pelizaeus-Merzbacher Disease
(metabolism)
- gamma-Aminobutyric Acid
(metabolism)
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