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Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.

Abstract
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.
AuthorsBryan D Choi, Carter M Suryadevara, Patrick C Gedeon, James E Herndon 2nd, Luis Sanchez-Perez, Darell D Bigner, John H Sampson
JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 21 Issue 1 Pg. 189-90 (Jan 2014) ISSN: 1532-2653 [Electronic] Scotland
PMID24054399 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Receptors, Antigen, T-Cell
  • epidermal growth factor receptor VIII
  • ErbB Receptors
Topics
  • Animals
  • Brain Neoplasms (immunology)
  • Cell Line, Tumor
  • Chimera
  • ErbB Receptors (genetics, immunology)
  • Glioma (immunology)
  • Humans
  • Immunotherapy (methods)
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Receptors, Antigen, T-Cell (immunology)
  • Transduction, Genetic
  • Xenograft Model Antitumor Assays

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