HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Efficacy and safety of pregabalin for oxaliplatin- and paclitaxel-induced peripheral neuropathy].

Abstract
This study included patients who were prescribed pregabalin, vitamin B12, amitriptyline, clonazepam, or carbamazepine to improve oxaliplatin(L-OHP)- or paclitaxel(PTX)-induced peripheral neuropathy at Iwate Medical University Hospital between April 2011 and July 2012. The efficacy and safety of pregabalin was evaluated by comparing 27 patients with L-OHP-induced peripheral neuropathy and 28 with PTX-induced peripheral neuropathy prescribed pregabalin(pregabalin group) with 20 patients with L-OHP-induced peripheral neuropathy and 25 with PTX-induced peripheral neuropathy prescribed other drugs(non-pregabalin group). Response was defined as a decrease in neuropathy of at least 1 grade from baseline. The response rates were 40.7% and 10.0% for L-OHP-induced peripheral neuropathy patients and 28.6% and 12.0% for PTX-induced peripheral neuropathy patients in the pregabalin and non-pregabalin groups, respectively. The severity of peripheral neuropathy before and after the administration of pregabalin differed significantly[L-OHP, 1.33±0.48(mean±SD) vs. 1.00±0.78 and PTX, 1.46±0.69 vs. 1.21±0.88]. In 28-37% of patients, pregabalin was associated with adverse events, with drowsiness and dizziness being frequently observed. In conclusion, pregabalin was efficacious in reducing the severity of L-OHP- and PTX-induced peripheral neuropathy.
AuthorsSatoru Nihei, Junya Sato, Masahiro Kashiwaba, Tetsuya Itabashi, Kenzo Kudo, Katsuo Takahashi
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 9 Pg. 1189-93 (Sep 2013) ISSN: 0385-0684 [Print] Japan
PMID24047777 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Oxaliplatin
  • Pregabalin
  • gamma-Aminobutyric Acid
  • Paclitaxel
Topics
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Neoplasms (drug therapy)
  • Organoplatinum Compounds (adverse effects, therapeutic use)
  • Oxaliplatin
  • Paclitaxel (adverse effects, therapeutic use)
  • Peripheral Nervous System Diseases (chemically induced, drug therapy)
  • Pregabalin
  • Retrospective Studies
  • gamma-Aminobutyric Acid (adverse effects, analogs & derivatives, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: