Abstract |
This study included patients who were prescribed pregabalin, vitamin B12, amitriptyline, clonazepam, or carbamazepine to improve oxaliplatin(L-OHP)- or paclitaxel(PTX)-induced peripheral neuropathy at Iwate Medical University Hospital between April 2011 and July 2012. The efficacy and safety of pregabalin was evaluated by comparing 27 patients with L-OHP-induced peripheral neuropathy and 28 with PTX-induced peripheral neuropathy prescribed pregabalin( pregabalin group) with 20 patients with L-OHP-induced peripheral neuropathy and 25 with PTX-induced peripheral neuropathy prescribed other drugs(non- pregabalin group). Response was defined as a decrease in neuropathy of at least 1 grade from baseline. The response rates were 40.7% and 10.0% for L-OHP-induced peripheral neuropathy patients and 28.6% and 12.0% for PTX-induced peripheral neuropathy patients in the pregabalin and non- pregabalin groups, respectively. The severity of peripheral neuropathy before and after the administration of pregabalin differed significantly[L-OHP, 1.33±0.48(mean±SD) vs. 1.00±0.78 and PTX, 1.46±0.69 vs. 1.21±0.88]. In 28-37% of patients, pregabalin was associated with adverse events, with drowsiness and dizziness being frequently observed. In conclusion, pregabalin was efficacious in reducing the severity of L-OHP- and PTX-induced peripheral neuropathy.
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Authors | Satoru Nihei, Junya Sato, Masahiro Kashiwaba, Tetsuya Itabashi, Kenzo Kudo, Katsuo Takahashi |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 40
Issue 9
Pg. 1189-93
(Sep 2013)
ISSN: 0385-0684 [Print] Japan |
PMID | 24047777
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Organoplatinum Compounds
- Oxaliplatin
- Pregabalin
- gamma-Aminobutyric Acid
- Paclitaxel
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Topics |
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Neoplasms
(drug therapy)
- Organoplatinum Compounds
(adverse effects, therapeutic use)
- Oxaliplatin
- Paclitaxel
(adverse effects, therapeutic use)
- Peripheral Nervous System Diseases
(chemically induced, drug therapy)
- Pregabalin
- Retrospective Studies
- gamma-Aminobutyric Acid
(adverse effects, analogs & derivatives, therapeutic use)
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