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Septins in the glial cells of the nervous system.

Abstract
The capacity of cytoskeletal septins to mediate diverse cellular processes is related to their ability to assemble as distinct heterooligomers and higher order structures. However, in many cell types the functional relevance of septins is not well understood. This minireview provides a brief overview of our current knowledge about septins in the non-neuronal cells of the vertebrate nervous system, collectively termed 'glial cells', i.e., astrocytes, microglia, oligodendrocytes, and Schwann cells. The dysregulation of septins observed in various models of myelin pathology is discussed with respect to implications for hereditary neuralgic amyotrophy (HNA) caused by mutations of the human SEPT9-gene.
AuthorsJulia Patzig, Michelle S Dworschak, Ann-Kristin Martens, Hauke B Werner
JournalBiological chemistry (Biol Chem) Vol. 395 Issue 2 Pg. 143-9 (Feb 2014) ISSN: 1437-4315 [Electronic] Germany
PMID24047595 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • SEPTIN9 protein, human
  • Septins
Topics
  • Animals
  • Astrocytes (metabolism)
  • Brachial Plexus Neuritis (metabolism)
  • Humans
  • Microglia (metabolism)
  • Nervous System (cytology, metabolism)
  • Neuroglia (metabolism)
  • Oligodendroglia (metabolism)
  • Schwann Cells (metabolism)
  • Septins (genetics, metabolism)

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