Abstract | AIM: The aim of this study was to evaluate clinical usefulness of cathepsin D status in early breast cancer during the first 3 years of follow-up. PATIENTS & METHODS: RESULTS: On the basis of differences in cathepsin D levels either within an ER(-)/PR(-) phenotype or between this and either ER(+)/PR(+) or ER(+)/PR(-) phenotypes, a concentration of 39 pmol/mg was determined as the cutoff value for distinguishing estrogen-regulated cathepsin D expression. Estrogen-regulated cathepsin D expression was recognized as a high-risk biomarker for low-risk (histological grade I) breast cancer patients and as a low-risk biomarker for high-risk patients (pN(+) pT2,3). CONCLUSION: Determination of cathepsin D status in breast cancer might identify patients at different risk for relapse and might facilitate the selection of more or less aggressive adjuvant therapy for early breast cancer patients during the first 3 years of follow-up.
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Authors | Milan Markićević, Ksenija Kanjer, Vesna Mandušić, Marko Buta, Zora Nešković-Konstantinović, Dragica Nikolić-Vukosavljević |
Journal | Biomarkers in medicine
(Biomark Med)
Vol. 7
Issue 5
Pg. 747-58
(Oct 2013)
ISSN: 1752-0371 [Electronic] England |
PMID | 24044567
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Cathepsin D
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Topics |
- Adult
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(diagnosis, enzymology, pathology)
- Cathepsin D
(metabolism)
- Cytosol
(enzymology)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Retrospective Studies
- Tumor Burden
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