Abstract |
Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.
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Authors | Anna Guerra, Mario Carrano, Elisabetta Angrisani, Mario Vitale |
Journal | Recenti progressi in medicina
(Recenti Prog Med)
Vol. 104
Issue 7-8
Pg. 415-9
( 2013)
ISSN: 0034-1193 [Print] Italy |
Vernacular Title | Valore diagnostico degli oncogeni BRAFV600E e RET/PTC nei noduli tiroidei. |
PMID | 24042420
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- DNA, Neoplasm
- Oncogene Proteins, Fusion
- Protein-Tyrosine Kinases
- ret-PTC fusion oncoproteins, human
- BRAF protein, human
- Proto-Oncogene Proteins B-raf
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Topics |
- Adenocarcinoma, Follicular
(chemistry, diagnosis, genetics, pathology, surgery)
- Biomarkers, Tumor
(analysis)
- Biopsy, Fine-Needle
- Carcinoma, Papillary
(chemistry, diagnosis, genetics, pathology, surgery)
- DNA, Neoplasm
(genetics)
- Diagnosis, Differential
- Humans
- Mutation, Missense
- Oncogene Proteins, Fusion
(genetics)
- Oncogenes
- Point Mutation
- Protein-Tyrosine Kinases
(genetics)
- Proto-Oncogene Proteins B-raf
(genetics)
- Retrospective Studies
- Sensitivity and Specificity
- Thyroid Diseases
(diagnosis, genetics, pathology, surgery)
- Thyroid Neoplasms
(chemistry, diagnosis, genetics, pathology, surgery)
- Thyroid Nodule
(chemistry, genetics, pathology, surgery)
- Thyroidectomy
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