Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth.

Abstract

OBJECTIVE:

The aim of this study was to investigate the clinical factors in relation to the cyclosporine A (CsA) induced gingival overgrowth (GO).

STUDY DESIGN:

Seventy-three participants were assigned as GO+ and GO-. Factors including demographic, pharmacological, gingival variables and the serum cyclophilin A (CyPA) concentration were analyzed.

RESULTS:

The occurrence of GO was 39.72%. Papillary bleeding index (PBI) had a significantly higher risk of GO than plaque index (PI), the ratio of CsA to CyPA, and serum CyPA concentration (odds ratio = 364.323, 25.791, 1.002, 0.096, respectively). The severity of GO correlated with PI, the ratio of CsA to CyPA, PBI, serum concentrations of CsA and CyPA (r = 0.366, 0.355, 0.344, 0.305, and -0.232, respectively).

CONCLUSIONS:

Since a cross-sectional study is not able to explain whether plaque and inflammation are the cause or consequence of GO, the ratio of CsA to CyPA may be a valuable marker for predicting GO.

• Authors: Lei Jiang, Ming Jing Gao, Jie Zhou, Jing Zhao, Shu Wei Zhao, Yun Fu Zhao
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 116 Issue 4 Pg. 447-54 (Oct 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 24035111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Immunosuppressive Agents
• Cyclosporine
• Cyclophilin A

Topics

• Adult
• Analysis of Variance
• Cross-Sectional Studies
• Cyclophilin A (blood)
• Cyclosporine (administration & dosage, adverse effects)
• Dental Plaque Index
• Enzyme-Linked Immunosorbent Assay
• Female
• Gingival Overgrowth (chemically induced, pathology)
• Humans
• Immunosuppression Therapy (adverse effects)
• Immunosuppressive Agents (adverse effects)
• Kidney Transplantation
• Luminescent Measurements
• Male
• Middle Aged
• Severity of Illness Index